Antibacterial principle and application case of PHMB
Product name: PHMB
Chemical name: Polyhexamethylene Biguanide Hydrochloride
CAS number: 32289-58-0
Purity: 98% powder; 20% liquid;
Specification
Item | PHMB 20% Solution | PHMB 98% powder |
Effective content | 20% | ＞99% |
Water soluble | completely dissolved | completely dissolved |
Main ingredient | PHMB | PHMB |
PH(25℃) | 4-6 | 5-9 |
Absorbance 236/220nm | 1.2-1.6 | —— |
Absorbance 1%/236nm | ≥400 | —— |
PHMB performance characteristics:
High efficiency
--only a small amount of addition can show excellent antibacterial, anti-mildew, and algae killing effects, with an average killing rate of 99.99%;
Safety
--no toxic side effects, no irritation to the skin, mucous membranes, eyes, no skin allergies to it;
Stable
--stable to light and heat; stable in a wide range of pH (PH=1～11);
Long-acting
--no bacterial resistance, long-lasting effect;
Easy to operate
--the items to be treated can be treated by rubbing, spraying, soaking, etc.;
Environmentally friendly
--colorless, odorless, non-volatile, free of heavy metals, halogens, phenols, and aldehydes, and non-corrosive to various surface treatments;
Antibacterial principle:
PHMB is a cell membrane active antibacterial agent. Its inhibitory effect on bacterial activity is higher than that on fungi. Its antibacterial mechanism is roughly as follows:
1. Broad-spectrum antibacterial, with obvious antibacterial effect, and has the ability to inhibit Gram-positive bacteria, Gram-negative bacteria, fungi (various ringworms and molds) and yeasts.
2. PHMB is a polycationic compound, which will be adsorbed on the surface of negatively charged microorganisms to prevent them from dividing and multiplying.
3. PHMB adsorbed on the surface of microorganisms acts on the phospholipid bilayer in the cytoplasm through transmembrane transport, and combines with negatively charged phosphate groups, thereby changing the selective permeability of the cell membrane, destroying cell metabolism, and inhibiting microorganisms.
4. PHMB: LD50>5000mg/kg, friendly to skin, can be used for a long time, friendly to human body and environment.
Application case：
1) Daily disinfection
It can be used for household and environmental disinfection, object surface disinfection and hand disinfection. It can inhibit Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and other bacteria, as well as common fungi and molds in the environment such as Candida albicans and Aspergillus niger.
2) Antivibrio in aquaculture
It has inhibitory effect on Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio floating, Vibrio harveylius, Vibrio anguillarum and Vibrio nereis, and can be used for disinfection of breeding environment. Adding this product in the process of water cycle treatment can enhance the activity of water, reduce ammonia and nitrate in water, control the growth of algae, and naturally balance the ecosystem of sea cucumber ponds and fish and shrimp ponds.
3) Antibacterial and antiseptic for agricultural fruits and vegetables
Treat seeds, bulbs or tubes. Solve vegetable diseases and solve soil problems; improve soil quality, and can be used for fresh-keeping and anti-corrosion of vegetables and fruits.
4) Textile printing and dyeing industry
It can have good antibacterial performance against common microorganisms, and at the same time can disperse and eliminate the sticky matter produced during the precipitation process. Dilute directly with purified water or use in combination with other additives. It is used for disinfection and antibacterial of the surface and air of clothes, towels, bed sheets and other kinds of fabrics.
5) Skin disinfection
The product used is a cationic polymer, and its antibacterial effect is mainly through dissolving lipids, changing the permeability of the bacterial cell membrane, and making the metabolism in the bacteria hinder and antibacterial. It has a wide antibacterial spectrum and is friendly to the skin.
